10% of the population has been shown to suffer from Pyrrole Disorder (Pyroluria). This blood disorder can be a significant root cause of MANY mood disorders such as bipolar disorder, addictive disorders, anxiety, depression alcoholism, spectrum disorders, and ADHD.
What Is Pyrrole Disorder?
Pyrrole Disorder is a condition where the body overproduces kryptopyrroles (pyrroles) as a byproduct of hemoglobin production (red blood cell production). In a healthy system, these pyrroles are excreted through the urine. HOWEVER, in some individuals, pyrroles multiply too rapidly, leading to an excess that remains in the bloodstream. This excess binds to and depletes essential nutrients like zinc and vitamin B6, preventing the body from utilising them properly, setting off a whole host of issues in the body.
As a result, those with Pyrrole Disorder often have high copper to zinc ratios as well and increased oxidative stress. This can be triggered by trauma, prolonged stress, poor diet or gut issues. Gut issues are highly linked to pyroles and exacerbated the presentation including high associations with leaky gut, SIBO and gut dysbiosis.
There is a possible epigenetic link with pyrroles however, this is triggered via the environment NOT just the genes. For example, long-term antibiotic use or undiagnosed Celiac disease can trigger the genes to turn on.
Symptoms of Pyrrole Disorder
Pyrrole Disorder can manifest in various ways, often leading to long-term health challenges. Common symptoms include:
High irritability and mood swings
Poor stress management
Anxiety and depression
Short temper
Anaemia
Gut issues - bloating, constipation, diarrhoea
Frequent infections
Sensitivity to light, odors, and textures
Cold sores and skin conditions that don’t fully heal
Acne
Joint pain
Premature graying
White spots on fingernails
Morning nausea and low appetite in the morning
Poor dream recall
How Pyrrole Disorder Links to Eating Disorders
Due to the depletion of zinc and vitamin B6, Pyrrole Disorder can significantly impact neurotransmitter production, leading to increased anxiety, depression, and obsessive thoughts. Zinc is essential for proper appetite regulation and digestion, and its deficiency can result in a disordered relationship with food. Many individuals with Pyrrole Disorder struggle with appetite dysregulation, cravings, and emotional eating patterns, often mistaking their biochemical imbalances for willpower issues.
Additionally, because those with Pyroluria often have a compromised gut lining, they may experience difficulties digesting proteins and fats, leading to bloating, nausea, and food aversions. This can create a cycle of restrictive eating, binge eating, or extreme dietary behaviors in an attempt to feel better, further exacerbating nutritional imbalances. Addressing these deficiencies can be an ABSOLUTE game-changer for anyone dealing with disordered eating patterns. This might be the final piece of the puzzle you are looking for as it is so incredibly hard to deal with eating disorders through trying ton consciously rewire the brain, trust me, I've been there, I get it!
The Role of Neurotransmitters
Zinc and vitamin B6 play a crucial role in neurotransmitter production, including:
GABA – Helps to calm the brain and reduce anxiety
Dopamine – Involved in motivation, focus, and mood regulation
Serotonin – Supports mood stability and reduces stress
A deficiency in these nutrients can lead to neurotransmitter imbalances, increasing anxiety, mood swings, and even symptoms of ADHD.
Testing for Pyrrole Disorder
If you suspect Pyrrole Disorder may be affecting you, testing can confirm your levels and guide a treatment plan. Recommended tests include:
Urine testing – To measure pyrrole levels (borderline: 10-20 mcg/dL, positive: 20+ mcg/dL)
Blood testing – To assess zinc, copper, and other nutrient levels
Further functional testing – Depending on symptoms, stool analysis, SIBO breath testing, blood chemistry, and hair tissue mineral analysis may be suggested
How to Support Your Body Naturally
Managing Pyrrole Disorder involves addressing underlying deficiencies and supporting gut health. Key dietary changes include:
Removing gluten – To reduce gut permeability and brain inflammation
Eliminating dairy – Due to its inflammatory and immune-reactive properties
Avoiding sugar – To stabilize blood sugar and prevent adrenal stress
Eating a nutrient-dense diet – Focused on whole foods, healthy fats, and protein
What’s Next?
If you’re experiencing anxiety, mood swings, or disordered eating patterns that don’t seem to improve with traditional approaches, Pyrrole Disorder could be an underlying factor. The good news? With the right nutritional and supplemental support, symptoms can be managed effectively.
Book a 1:1 consultation with me to assess your symptoms and receive a tailored plan, including personalised supplement recommendations to support your healing journey. Let’s get to the root of your health concerns and help you feel your best again!
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